Fornasiero LAB

Our lab is interested in presynaptic physiology focusing on the mechanisms that regulate neuronal development and aging

Previous and current research

Our overall goal is to elucidate the molecular principles underlying protein turnover in the brain, with a particular focus on neuronal development and aging.

We are also working on a series of labeling techniques using super-resolution microscopy and mass spectrometry technologies to study protein stability and turnover in vitro and in vivo in various model systems.

Stay tuned!

Projects and collaborations

Current projects in the lab aim to:

• Investigate the principles that regulate synaptic vesicle biogenesis and degradation using state-of-the-art microscopy.
• Elucidating the biological processes underlying brain aging using multiomic approaches and bioinformatics.
• Investigate the basis of macromolecular turnover in the brain with a focus on neuronal development and physiology.

In the future, we will extend the use of metabolic labeling to other model organisms and biological conditions, and explore the possibility of using impulse labeling to address a more general set of dynamic questions in brain biology.
Our close collaborators include Prof. Dr. Silvio O. Rizzoli (University Medical School, Göttingen) and Dr. Felipe Opazo (Center of Biostructural Imaging of Neurodegeneration, Göttingen).